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Getting a patient diagnosed and prescribed is hard. Keeping them on therapy long enough to see real benefit? That's often even harder — and the stakes couldn't be higher.

Most medications don't deliver their full effect after a single fill. Antidepressants require weeks of consistent use before therapeutic stabilization sets in. Biologics for chronic skin conditions need time to modulate the immune response. Long-term maintenance therapies only work if patients actually maintain them. When patients drop off early, they don't just generate less revenue for the brand — they frequently don't get better.

For pharma and life sciences brands, the gap between prescription and persistence is therefore one of the most costly — and underaddressed — challenges in the business. Patients discontinue therapy for a wide range of reasons: they forget refills, lose touch with their specialist, or simply don't feel the urgency to continue a medication when symptoms aren't immediately visible. The result is a cycle of drop-off that undermines both patient outcomes and brand performance.

Nimble, the platform modernizing independent and regional pharmacy operations, has developed a data-driven approach to solving this problem — and the results across multiple therapeutic areas are compelling.

The Core Idea: Meeting Patients at the Moment That Matters

Nimble's patient engagement programs work through the pharmacy layer — a touchpoint that's often overlooked in DTC and patient support strategies but sits at the critical junction between prescription and actual medication use. By leveraging precise digital outreach, Nimble can identify targeted patient populations and deliver timely, relevant interventions that keep them connected to their care plans.

The approach isn't one-size-fits-all. Nimble tailors its programs to the specific clinical and behavioral challenges of each therapy area — whether that's addressing the high discontinuation rates common in mental health, re-engaging patients who've drifted away from specialist care, or sustaining adherence for long-term maintenance medications.

What the Data Shows

Nimble recently published a new case study documenting outcomes across three distinct therapeutic programs: a mental health indication, a dermatology program targeting chronic skin conditions, and a women's health maintenance therapy.

Across all three, the results point in the same direction: patients who receive Nimble's digital support are meaningfully more likely to stay on therapy, refill their prescriptions, and remain engaged with their care providers.

A few highlights from the data:

• Adherence improvements were consistent and significant across all three programs — not marginal gains, but the kind of lift that moves the needle on persistence curves and lifetime patient value.
• Specialist engagement increased substantially in the dermatology program, with targeted outreach driving patients back to their physicians at rates well above the control group.
• New-to-brand starts surged when Nimble identified and activated treatment-naive patients who had previously been managing their condition on inadequate therapies.
• Long-term adherence continued to climb month over month in the women's health program, with dispensed quantities also increasing — a strong indicator that patients weren't just refilling, but actually taking their medication.

Why This Matters for Pharma Brand Teams

For brand managers and patient support leads, the commercial implications of improved persistence are straightforward: more refills, longer treatment duration, and prescriptions that convert into realized, ongoing therapy.

But the most important story here may be the patient outcome one. Medications only work when patients take them — and for most chronic conditions, the clinical benefit compounds over time. A patient with atopic dermatitis who stays on a biologic long enough experiences sustained skin clearance. A depression patient who remains on their antidepressant through the critical stabilization window is far more likely to achieve remission than one who discontinues after a few weeks. A woman who consistently fills her maintenance therapy reduces her long-term health risk in ways a single fill never could. Persistence isn't just a commercial metric — it's a proxy for whether the treatment actually worked. Nimble's programs address both dimensions simultaneously, turning better adherence into better outcomes for patients and better performance for brands.

The case study also speaks to the value of the pharmacy network as a patient engagement channel. Independent and regional pharmacies serve millions of patients who may have less access to the robust support infrastructure that surrounds large health systems. Nimble's technology brings a level of proactive, data-driven outreach to those patients that was previously difficult to achieve at scale.

Read the Full Case Study

The full case study includes detailed program data, outcome charts, and a breakdown of results by therapeutic area — giving brand and marketing teams a clear picture of what Nimble's interventions look like in practice and the kind of impact they can deliver.

Download the Case Study

To learn more about Nimble's patient engagement programs, visit nimblerx.com.

 

Pharma’s next growth market isn’t a new drug. It’s an underserved audience.

For decades, pharmaceutical marketing has prioritized scale over specificity, relying on broad campaigns designed to reach the “general market.” But as the United States becomes more diverse and patient expectations evolve, that definition no longer reflects reality.

Today, growth in healthcare is being driven by audiences that have historically been overlooked, particularly Black and multicultural consumers. These communities are disproportionately impacted by many chronic conditions, highly engaged in health decision-making, and increasingly influential in shaping cultural and consumer trends.

Yet, they are still not being reached in ways that feel meaningful or culturally sensitive.

This gap is not just a health equity issue. It’s a missed business opportunity.

The Business Case Has Changed

The U.S. is rapidly becoming more diverse, and with that shift comes a change in where growth will come from.

Black Americans represent more than $1.6 trillion in buying power, according to Nielsen, and account for an estimated $135 billion or more in annual healthcare spending. They also over-index in several high-priority therapeutic areas, including those associated with hypertension, diabetes, and asthma. These are conditions that require long-term management and ongoing engagement with care.

At the same time, multicultural consumers are shaping how health information is consumed, shared, and trusted.

For pharmaceutical companies operating in increasingly competitive categories, growth is no longer just about innovation. It depends on reach, engagement, and ongoing adherence.

And, all of that depends on trust.

The Data: Diverse Audiences Are an Economic Opportunity

Industry data tells a clear story. Diverse audiences are not difficult to reach; they are misunderstood.

Citing research from CMI Media Group, a recent report in MM+M suggests that Black and Hispanic consumers may be more receptive to pharmaceutical advertising than many marketers assume, especially when messaging feels relevant and credible.

Nielsen insights reinforce this. Black consumers demonstrate strong brand loyalty when trust is established and show high engagement across mobile, video, and culturally relevant media environments.

Industry data points to the size of the opportunity. Audience-level insights show what it takes to actually earn it.

The Trust Gap Is the Revenue Gap

Despite the opportunity, trust remains one of the most significant barriers and one of the clearest drivers of growth.

Historical inequities and lived experiences have created both mistrust and distrust in healthcare among Black patients. Mistrust can often be addressed with information. Distrust requires something more dedicated and intentional – consistent, credible engagement over time.

BlackDoctor audience-level insights reinforce this dynamic. They show that  trust does not start with messaging. It starts with meeting real needs.

In a 2024 survey of nearly 500 respondents, BlackDoctor found that:

• 74% said lowering the cost of treatment would make pharmaceutical companies more helpful
• More than 55% want tools like doctor visit checklists
• 54% want health information made easier to understand
• Over 40% want ways to track and better understand their symptoms

These are not just feature requests. They are early signs of trust. When patients feel supported and equipped to navigate their care, they are more open to engagement.

Still, meeting needs alone is not enough.

When asked what pharmaceutical companies should do to build trust:

• Nearly 47% said invest more in communities
• 40% called for more Black representation in pharma leadership
• More than 38% want greater visibility in the Black community
• Over 32% said communication should happen through Black-owned media platforms

The message is clear. Trust is built with presence, representation, and helping people in real ways. Messaging alone will not get you there.

You see this even more clearly when trust is broken.

In a separate BlackDoctor audience poll, more than 73% of respondents said they felt troubled or insulted when brands used Black representation in mainstream channels while failing to invest in Black-owned platforms. Many said it reduced their trust.

People are not just listening to what brands say. They are watching where and how they show up.

This is where business impact becomes clear.

If patients do not trust the message, they are less likely to seek care, start treatment, and/or stick to their treatment plan.

That directly influences ongoing-adherence and, ultimately, revenue. Medication non-adherence alone is estimated to cost the U.S. healthcare system more than $300 billion annually.

If trust drives adherence, and adherence drives revenue, then trust directly impacts the bottom line.

Why Pharma Has Missed the Mark

Despite growing awareness around diversity, equity, and inclusion, many pharmaceutical marketing strategies have yet to fully evolve.

Analysis from Pharmaceutical Executive points to a familiar pattern. There is strong intent, but inconsistent execution, especially when it comes to embedding cultural nuance into marketing and engagement strategies.

Too often, Black and Brown audiences are treated as secondary segments or campaign extensions, rather than core drivers of growth.

At the same time, many brands continue to rely on broad “general market” approaches, even as the market becomes more culturally defined.

In many cases, the gap is not awareness. It is execution.

Pharma has scaled its messaging. It has not scaled its credibility.

What Winning Looks Like

For pharmaceutical companies looking to unlock this opportunity, success requires a shift in mindset and strategy.

1. Invest in Trusted Platforms

Trust cannot be manufactured. It has to be built or strengthened through the right partnerships. More brands are recognizing the value of culturally rooted platforms, like BlackDoctor which has spent over 20 years earning credibility through consistent, community-centered engagement with both audiences and the healthcare professionals (HCPs) who serve them.

These environments operate differently than traditional media. They do more than deliver impressions. They help shape and influence real decisions over time.

2. Move Beyond Awareness to Education

Patients are not just looking for messaging. They are looking for guidance.

Content that is practical, culturally relevant, and easy to understand – whether it is checklists, explainers, or real patient stories – creates a clear path from awareness to action. Platforms are also beginning to use tools like AI to make that guidance more accessible, delivering information in ways that reflect the audience and the healthcare professionals they trust. When done well, these tools can help people better navigate complex conversations and feel more confident in their decisions.

3. Reflect the Audience Authentically

Representation matters, but relatability is what makes it stick. Messaging needs to reflect lived experiences, cultural context, and real-world concerns to truly resonate. People want to see themselves in the story and feel understood, not marketed to. That means creating content that is not only accurate, but culturally relevant, grounded in real experiences and delivered in environments where people feel safe learning about their health. When this happens the message doesn’t just land. It builds trust and encourages action.

4. Measure What Matters

Traditional metrics like impressions and reach only tell part of the story.

Leading organizations are focusing on indicators that reflect real impact:

• Engagement
• Treatment initiation
• Ongoing-Adherence
• Long-term trust

The Competitive Advantage

The pharmaceutical companies that lead in the next decade will not simply be those with the most innovative pipelines.

They will be the ones who understand how to build trust and sustain it.

When engagement is rooted in trust, the impact goes further. It influences decision-making, strengthens relationships, and drives long-term value.

The future of pharmaceutical marketing is not broader. It is more precise, more culturally sensitive, and more human.

And for the companies willing to embrace that shift, the opportunity is not just to reach more patients by spending marketing dollars on general market platforms.

It is to meet them where they are, where trust already exists with the brands who know and can reach these diverse audiences better and where action is far more likely to follow.

Sources include: Nielsen Diverse Intelligence Series; MM+M (CMI Media Group research); Pharmaceutical Executive; Annals of Internal Medicine; WHO; CDC; CMS; KFF; and proprietary audience insights from BlackDoctor.com.

Pharmaceutical direct-to-consumer (DTC) marketing has grown increasingly complex. Today’s patients and caregivers don’t engage with brands in a straight line; they move seamlessly between streaming platforms, social media, search engines, display ads, and even offline channels. From their perspective, it’s one continuous experience—not a collection of separate campaigns.

Yet many pharma marketers still build and execute campaigns in channel silos: programmatic, social, digital, broadcast, streaming, etc. While there’s value in this specialization, it often comes at a cost. When audiences are fragmented across channels, omnichannel execution is nearly impossible.

The Problem with Channel Silos: Fragmented Audiences

Many omnichannel strategies fall short because they are built on disconnected audience segments. Each channel often operates with its own targeting logic, datasets, and measurement frameworks. While campaigns may appear coordinated on the surface, the underlying audiences are fragmented. This leads to:

• Inconsistent messaging: Patients may receive disjointed or repetitive communications
• Poor sequencing: Campaigns fail to build on prior interactions
• Limited visibility: Marketers struggle to understand true performance across channels

True omnichannel activation starts with a shift in perspective—from channel-centric planning to audience-centric execution.

Defining an Omnichannel Audience

An omnichannel DTC audience is one that can be activated across multiple channels without losing its integrity. It maintains consistent identity and targeting logic regardless of where engagement happens.

• Cross-Channel Reach: The same audience can be engaged across TV, digital, social, and point-of-care environments without rebuilding segments from scratch.
• Consistent Identity Resolution: Individuals are recognized accurately across platforms using privacy-safe methods, ensuring continuity in messaging.
• Seamless Measurement: Performance can be tracked holistically, allowing marketers to understand how different touchpoints contribute to outcomes.

In other words, an omnichannel audience is a portable audience—one that can move seamlessly across channels without losing identity, context, or continuity. Without this portability, even the most sophisticated campaigns become fragmented and inefficient.

The Benefits of Audience Portability

Portable audiences allow marketers to define a group once and activate it across multiple channels without losing consistency. Instead of rebuilding segments for each platform, you maintain a unified view of who you’re trying to reach.

This approach unlocks several advantages:

• Consistent Messaging Across Touchpoints: Messaging can be coordinated and reinforced across every channel, creating a more coherent narrative that improves understanding and recall
• Smarter Sequencing and Timing: Greater control over the order and timing of exposures allows messaging to evolve logically—from awareness to action
• Better Frequency Management: A unified strategy helps ensure the right level of engagement without redundancy or wasted spend
• Clearer Measurement and Attribution: Portable audiences provide a more accurate view of performance across the full journey, making optimization more effective

The Other Cost of Fragmentation: Collaboration

One of the most overlooked drawbacks of fragmented audiences is how they affect collaboration. Silos create friction, duplicate work, and make it difficult to align on performance. Success is often defined differently depending on the channel or team.

Portable, omnichannel audiences give teams a shared foundation—a single view of brand-eligible patients. This alignment makes execution more seamless and optimization more effective. For leaders, it also provides clarity and confidence that every effort is moving in the same direction.

Moving Toward a Unified, Omnichannel Approach

Today’s channel-based DTC audiences may reflect how media teams are commonly structured, but they don’t align with demand for omnichannel strategies.

For life science marketers and media teams navigating rising costs, increased scrutiny, and higher expectations, audience portability isn’t a nice-to-have. It’s a performance advantage. By prioritizing portability, marketers can reach patients more effectively, deliver more relevant experiences, and increase marketing impact.

Omnichannel success doesn’t come from being everywhere—it happens when marketers create a unified journey that advances patients towards a better heath outcome. That means performance isn’t driven by any single tactic, but by how well your channels work together. And that coordination can’t be built on fragmented audiences.

About OptimizeRx

OptimizeRx is redefining how life science brands connect with patients and healthcare providers. By bridging the gap between HCP and DTC strategies, we empower brands to create synchronized marketing solutions that drive faster treatment decisions and improved patient outcomes.

Our privacy-safe, patented Micro-Neighborhood® technology combines brand-specific precision with channel-ready flexibility, using HIPAA-compliant medical, demographic, geographic, and media behavior data to find patients at or near brand eligibility, the create audiences that can be easily activated on all major media channels and onboarding platforms. It’s seamless, precise, and compliant—for omnichannel marketing that outperforms the competition. Learn more.

Changes in Patient Behaviors and Expectations Are Driving Shifts in Go-to-Market Strategies

The post-COVID era has normalized virtual healthcare, with telemedicine and home delivery now seen as standard expectations. Since 2022, most sources say that more than 30% of people used telemedicine services in the prior year, signaling a lasting shift toward digital-first care.

At the same time, there has been record-breaking e-commerce activity—such as Black Friday and Cyber Monday in 2024, where sales through Shopify hit a record $11.5B—reshaping consumer behavior. Trends like mobile and social shopping, along with buy-online-pickup-in-store (BOPIS) models, are influencing how patients expect to access medications. Compounding pharmacies and generic manufacturers have embraced these expectations, allowing patients to obtain many prescriptions through e-commerce-style experiences. Companies like Hims have demonstrated the power of this model, growing into a $7.5B business.

With the healthcare system stretched to capacity—especially in specialty care—virtual fulfillment offers a way to relieve pressure by streamlining access for patients who don’t require an in-person visit with a healthcare provider, allowing them to engage with a doctor via video or asynchronously via messaging. In response, over the past few years, many pharmaceutical brands have been launching white-labeled telemedicine and fulfillment platforms within brand.com to make treatment access faster and more convenient.

Larger manufacturers are scaling these efforts enterprise-wide: Eli Lilly introduced Lilly Direct in January 2024, and Pfizer launched PfizerForAll in August 2024; both platforms are designed to centralize patient education, support, and treatment information while giving patients greater control and clarity in how they obtain their medications.

While the initial DTP solutions have focused on lifestyle medications, driven by the GLP-1s, these solutions are poised to support treatments in areas that are low touch, and don’t really need specialist intervention. We’re starting to see that come to fruition, with solutions rolling out to support drugs in the asthma, lipid management, and migraine spaces.

Government and FDA Policy Shifts Are Accelerating the Rollout of Discounts and Direct-to-Patient (DTP) Solutions with Large Manufacturers

On May 12, 2025, the White House announced the Most-Favored-Nation Prescription Drug Price Presidential Action (MFN). MFN aims to reduce prescription drug prices and calls on the large pharmaceutical manufacturers to offer new ways for patients to access medications more affordably.

In June 2025, the FDA announced the Commissioner’s National Priority Voucher (CNPV) pilot program. This initiative, much like the existing FDA voucher program, grants accelerated approval for new drug launches. However, this new CNPV is only accessible to manufacturers “aligned with critical US national health priorities”—essentially incentivizing manufacturers to participate in MFN. This could change plans for in-market brands, as competitors may now launch sooner than originally planned—and at lower costs.

On September 29, 2025, PhRMA announced that it will support the White House’s programs, launching three actions that will deliver additional investments to the industry, provide further financial assistance to patients, and launch americasmedicines.com as a way to help patients access medications by consolidating DTP purchasing options for all medications and manufacturers. Shortly after, on September 30, the White House announced TrumpRx.gov, a website launching in January 2026, which allows patients to purchase medications as part of MFN directly.

From September through October 2025, the first partnerships under MFN have started to be announced, and it’s likely more will follow as the year continues:

• Partnership 1: Pfizer
  • This partnership, announced on September 30, 2025, aims to bring Pfizer drugs to all state Medicaid programs at discounts of up to 80% when purchased directly
• Partnership 2: AstraZeneca (AZ)
  • This partnership, announced on October 10, 2025, aims to bring AZ’s respiratory portfolio to all state Medicaid programs at discounts of up to 98% when purchased directly via AZPatientDirect.
• Partnership 3: EMD Serono
  • This partnership, announced on October 16, 2025, aims to expand access to IVF and fertility treatments, and will bring EMD Serono’s fertility portfolio (Gonal-F, Ovidrel, and Certrotide) at deep discounts to those purchasing directly from TrumpRx.gov, starting in January 2026. Low- or middle-income women will be able to access further discounts.

While not announced by the White House, on September 25, BMS announced the launch of BMS Patient Connect, which will allow cash patients to receive Sotyktu at an 80% discount beginning in January 2026. This was a follow-up to their announcement of Eliquis 360 Support in July. On October 6, Amgen introduced AmgenNow, offering Repatha at a 60% discount off the list price to all patients.

On October 16, the FDA also communicated the recipients of the first wave of accelerated approvals under CNPV, which also included Pergoveris, EMD Serono’s fertility medication (currently approved in the EU and Canada), which will likely launch in January 2026.

We’re also starting to see the first partnerships that are connecting these online DTP platforms with traditional retail pharmacy—leveraging the trend toward BOPIS in consumer commerce. On October 29, Lilly announced a partnership with Walmart pharmacy, which is the first retail partnership that enables a pick-up option with direct-to-consumer pricing for Zepbound.

While these partnerships and announcements seem positive on the surface for lowering prices and enabling greater access to needed medications, they likely aren’t bringing price relief too broadly, and patients may have to jump through hoops to receive the discounted prices:

• Only available for cash-paying patients
• Only available for select government-insured patients with specific income requirements
• A requirement to bundle multiple medications together from the same manufacturer
• A requirement to purchase the medication from a specific third-party pharmacy

Additionally, there are clear underlying incentives for pharmaceutical companies to participate in MFN beyond driving greater access to medications. Partnering with the administration can:

• Get pipeline drugs considered for the CNPV program for accelerated drug approvals in 1–2 months
• Reduce or waive tariffs on pharmaceutical imports

Confusingly, many of these announcements around DTP pharmaceutical sales coincided with the tightening of the rules and regulations around DTC pharmaceutical advertising, with the wave of FDA Untitled Letters issued to manufacturers on September 9. This tightening of DTC promotion is somewhat incongruent with driving patients to obtain medications directly.

A Timeline of Key Events

Examples of Manufacturer DTP Portals

 

What Does This Mean for Patients and Providers?

These changes have the potential to significantly improve how patients access their medications—making the process more convenient, flexible, and personalized. However, they also reshape the traditional role of the healthcare provider, introducing new dynamics in how care and fulfillment intersect.

Patients

For patients, these shifts can offer greater autonomy and control over their treatment experience. They may have more choices in how they pay for, receive, and manage their medications, which can enhance satisfaction and adherence. At the same time, the growing number of fulfillment options and support models may also create confusion. Patients may struggle to understand which programs apply to them, which are supported by their provider or insurer, and which option ultimately best serves their needs.

Additionally, as many of the discounted medications are only available under specific circumstances (e.g., for patients paying cash, those with specific government insurance, through a specific pharmacy, or bundled with other medications from that manufacturer), this could cause disappointment if patients don’t fully understand the offers.

Providers

For providers, these changes can bring both efficiency and complexity. On the positive side, a streamlined fulfillment process may free up time to focus on the patients who most need their expertise. However, as more manufacturers adopt unique DTP or hybrid distribution models, providers will need to adapt their workflows to manage incoming requests and coordinate with different pharmacies and platforms for fulfillment. Over time, this could even influence prescribing behavior—potentially fostering new forms of manufacturer loyalty based on ease of process, patient satisfaction, or administrative simplicity.

What Does This Mean for Marketers?

These shifts can create new opportunities for marketers, as regulatory precedents now support more customer-first branded solutions, and there are now more DTP capabilities that have become easier and faster to implement. However, there are also potential threats, especially for smaller biotechs, that must be carefully considered.

Opportunities

Virtual Fulfillment Experiences Are Now Table Stakes

Branded telehealth, fulfillment, and savings and support programs, once designed to address specific brand challenges, such as limited access or low coverage, are now becoming standard expectations. They must serve as a core component of a brand’s go-to-market strategy rather than a niche solution implemented for a specific need, but designing and implementing them through an impeccable customer experience is more important than ever.

Category Growth

In many therapeutic areas, expanded access options and manufacturer discounts may stimulate overall category growth. Patients who had previously discontinued treatment may re-enter the market to take advantage of these new solutions and reduced costs.

A More Holistic Brand Value Story & Broader Access

Historically, DTP efforts have focused on communicating co-pay support for commercially insured patients, often overlooking those without coverage or who would prefer to pay out of pocket. These new solutions allow brands to tell a more inclusive value story—one that addresses a broader range of patient needs, including discounted solutions for medicare/Medicaid patients—but doing so will require stronger internal and external alignment, particularly with managed markets teams. Additionally, these solutions may expand access to patients who are not in large metro areas or close to specialists

Threats

Risk of Patient Confusion and Switching

As the landscape continues to evolve, there’s a risk that satisfied patients may reconsider how or where they obtain their medication—or even switch to competitors offering these DTP solutions and/or discounts. It’s critical to clearly communicate that your brand remains easy to access, be transparent about cost and programs available, and to dispel any misconceptions that switching therapies offers an advantage. Brands should also be prepared to address patient questions about why certain DTP solutions and/or discounts are not currently part of their offering.

Unexpected Competitive Moves Eroding Market Share

• New DTP purchasing solutions or discounts for in-market brands drive share towards them
  • As larger pharmaceutical companies form more partnerships, they may introduce new DTP solutions or drug discounts for in-market brands that could undercut direct competitors. For smaller biotechs, it’s essential to scenario plan—anticipating how these shifts could impact the business and preparing proactive messaging or alternative fulfillment strategies.
• Accelerated approvals for new brands bring new options to market, potentially stealing share
  • Additionally, these partnerships for in-market brands may lead to accelerated approvals for new launches through the CNPV program. Brands should proactively monitor competitors’ pipelines, plan for the potential impact of early launches, and develop strategies to mitigate any resulting risks.

In Summary

Particularly for smaller biotechs, it’s valuable to establish a cross-functional DTP task force to proactively identify opportunities, anticipate risks, and monitor new announcements, partnerships, and launches. This task force should also evaluate the level of impact of any of these factors. In some cases, for example, where cash-pay volume is tiny, it may not actually equate to a large business impact.

As this space continues to evolve rapidly, staying nimble, agile, and prepared with a plan for likely scenarios will help minimize risk to your brand. We can help you proactively build a DTP strategy or competitive scenario plans to navigate this changing environment.

Progress is nothing without innovation, and innovation is impossible without exploring new frontiers. Embracing the new can be exhilarating. It can also be intimidating because it forces us to move beyond the comforting and familiar. Innovation doesn’t always render old models obsolete—sometimes, they may even come full circle to represent the real next frontier. 

Nothing better represents the promise and peril of the new than AI. AI tools are front and center in our online and office spaces while they also operate imperceptibly behind the scenes. It’s impact on our digital lives is profound. As we scroll through our socials, scanning content, swiping away ads, it’s right there in our faces, even if it doesn’t advertise itself. 

It’s easy to understand the attraction to AI. Of course, it’s shiny and new, but it also democratizes content generation in a way that wasn’t always possible. While the “artificial” in artificial intelligence is still front and center, AI content is becoming indistinguishable in some formats. The lines between reality and AI will continue to blur as the technology improves, and it will be harder to differentiate between the real and the artificial. 

This is the new frontier of content creation. From marketing emails and imagery to audio and video, the volume of automated content is growing quickly and evolving before our eyes. It’s fast, fluent, and frictionless, and it’s getting more sophisticated every day. 

AI saturation of communication is also fueling a shift we’ve seen coming for a while. AI has not and will not replicate authentic human experiences. No matter how much the digital space is flooded with synthetic stories, real human narratives, especially those that carry emotional weight, have become more valuable than ever. But as marketers continue churning out AI content, authenticity is quickly becoming a premium asset. Not because it’s novel, but because it works—and because, at our core, all of us crave real connection: to see ourselves in someone else’s experience and to know we are not alone. Consumers are used to seeking out real, authentic voices. And as real becomes rare, people will gravitate even more toward authentic content. 

Looking Back to Look Forward 

If this moment feels like déjà vu, it’s because we’ve been here before. A few decades ago, healthcare marketers began to question the industry’s reliance on staged testimonials, hired actors, and polished but generic messaging. It looked and sounded good, but it lacked authenticity, and people knew it. A small but growing number of people believed that real patients sharing real experiences could deliver something far more powerful: trust. Confidential – Not for Public Consumption or Distribution 

That idea sparked a quiet revolution and opened up the next frontier in pharma marketing: real, authentic patient stories. Over time, patient storytelling evolved from a niche offering to the industry standard, redefining the way healthcare brands engage with their most important stakeholders. This shift was something even the FDA acknowledged when it established its Patient-Focused Drug Development initiative in 2012 to more systematically collect patient experience and perspectives as part of regulatory and development decision-making. Today, authentic patient stories are a mainstay of modern life science communications, and the key to building trust. 

And that authenticity is just as important as it ever was. Even before AI, many of our live connections and interactions had been pushed online by COVID. While virtual can be a boon for some, it can also create a pronounced isolation for patients living with serious health conditions. Now, replacing real, authentic content with AI-generated content runs the risk of deepening patient isolation and chipping away at hard-won patient trust. 

Today, we find ourselves back at a similar inflection point. It’s no longer dramatization that stands in the way of authenticity but digitization. The new “fake” isn’t a paid actor; it’s a perfectly plausible AI-generated testimonial. And the new premium? It’s still the same as it was before: truth. 

Providing Proof of Authenticity 

What was true then is just as true now: patient audiences can spot the real from the fake. As the market gets better at producing content, audiences will get better at discerning what matters. In that environment, the real differentiator won’t be polish, it will be proof. Did a real person say this? Did this actually happen? Is there a real story behind the message? 

Going forward, simply claiming authenticity won’t be enough. Organizations will need to prove it. Regulatory conversations around AI transparency in advertising are already happening as we speak, and we’re seeing the start of a nascent verification era. The technology and policy are racing to catch up. Standards like C2PA (Coalition for Content Provenance and Authenticity), NIST (National Institute of Standards and Technology) protocols, and Google’s SynthID are establishing what could become digital signatures for truth. The goal of these technologies is to distinguish between human- and machine-generated content, giving creators a tool to validate the authenticity of their work. 

That matters, because audiences will demand it. For companies that have built their reputations on patient-centered work, verification tools for authentic stories will become critical. Some are already quietly aligning their processes with these tools because they recognize where the tide is going. 

Why Authenticity Matters to Healthcare Marketers 

In healthcare, trust isn’t optional. It’s everything. The messages we share have to ring true because they impact so much: treatment decisions, care choices, even the emotional journeys of people navigating serious diagnoses. 

Yes, generative AI carries promise. It enhances and augments productivity in ways that can improve healthcare marketers’ work: organizing information, interview preparation, Confidential – Not for Public Consumption or Distribution 

automating routine communications, even enhancing compliance. But it cannot duplicate human emotion or replace a real human voice. It cannot capture the emotional nuance of a patient facing a life-altering condition. 

None of this is a rejection of AI. It’s a call to use it wisely, embrace what it can do, and elevate what it can’t replicate. And stories cannot be replicated because they come from people, not prompts. AI may be able to mimic story structures or overlay messaging. But the real voice is key to creating a story that connects a brand to a patient. Protecting that real, authentic voice is an ethical imperative, but it’s also strategically smart. Authenticity builds connection, fosters credibility, and does something AI cannot: it makes people feel. 

Stepping Into the Future 

Some fear a future where AI devalues human creativity. But history suggests a different outcome. Photography did not erase art: it gave artists new tools to explore their creativity. Email did not destroy handwritten letters; it made them more meaningful. And streaming did not put an end to live concerts; it made them a premium experience. Automation increases creativity’s worth. And worth isn’t measured by profit alone, but by impact. The pioneers of the new frontier won’t be the ones who generate the most but those who make what’s real, authentic, and emotionally resonant.

In our third annual report on the state of brand planning, EVERSANA surveyed nearly 100 brand planning executives across biopharmaceuticals, diagnostics and medical devices. This year, we expanded our assessment by hosting 111 marketing leaders from around the globe at a client advisory board in Napa Valley, California, to hear firsthand about key advancements and persistent challenges in brand planning.

WHAT DID WE LEARN?

While an impressive 87% of respondents reported that brand planning helped meet customer and business goals, one advisory board participant summed up the underlying frustrations quite well: “It feels like we are planning for nine months, then executing for three months.” We hypothesize that some sources of this disconnect in overall satisfaction with the outcomes can be explained through more detailed areas of discussion.

INCREASINGLY EFFECTIVE MEASUREMENT THROUGH DATA AND ANALYTICS

We observed significant year-over-year advancement in leader sentiment regarding data and analytics, with two-thirds not only believing in the effective measurement of success in terms of execution against the brand plan and market results, but also that data and advanced analytics played a growing role in achieving this. Our discussion with leaders revealed two drivers:

• Leaders have increasingly been pressured through efficiency measures, in response to the macro environment (seen through operational expenditure and headcount rationalization), to demonstrate the value of marketing, medical and market access investments – forcing greater examination of the returns on these investments.
• Client and service provider data and analytics platforms continue to mature, enabling more client organizations to turn metadata into timely and accurate insights.

PERSISTENT CHALLENGES WITH DIGITAL CAPABILITIES AND GENERATIVE AI

Surprisingly, we continue to see more than half of our industry’s leaders expressing concerns about being equipped and experienced to leverage digital capabilities, specifically generative AI. Upon further investigation, it appears that expectations here continue to grow exponentially from the boardroom and C-suite, even though partners are still in the early stages of adoption and struggling to keep pace with the hype.

PARTNER ROSTER: AN ADDITIONAL SOURCE OF DISCONTENT

Where we observed the lowest satisfaction from leaders and a steep decline over the last three years was in the belief that external partners (e.g., agencies, market researchers, consultants) collaborated effectively and integrated their contributions for the betterment of the brand plan. While the promise of consolidation – particularly in the agency segment of partners – has been to aid this, we continue to hear some clients are feeling uneasy about being forced into working with preferred vendors based on enterprise agreements while remaining on the hook for the outcomes.

CONCLUSION

Brand and portfolio leaders can often feel overwhelmed by the annual brand planning process, as well as the capabilities and partners required to ensure that cross-functional insights, strategy and execution will lead to projected results. In situations like these, EVERSANA’s Next-Generation Brand Planning can be leveraged to partner experienced strategic leads with brand teams to seamlessly and efficiently guide the process, assist integration and enable focus that drives business results.

Want to dive into the full results of our experts' research and its implications on brand planning? Contact the authors to learn more.

Biopharma companies face increasing challenges engaging patients, and patients face increasing challenges accessing timely, personalized, and convenient healthcare. Despite increased investment in product promotion, 1 in 4 patients still avoid seeking care and treatment because it’s inconvenient¹. This gap between patients and the care they need underscores an urgent call for innovative solutions that not only connect patients to care but also simplify their journey from diagnosis to treatment.

Patients expect more from biopharma. A 2025 research study by ixlayer and Ipsos found that 81% of survey respondents think that pharma companies should help them get the care and medicine they need.²

Configurable direct-to-patient (DTP) platforms are designed to bridge this divide. By connecting the disparate components of the healthcare ecosystem—patients, labs, providers, payments, prescriptions, and more—these platforms empower biopharma companies to support and elevate the patient experience across any therapeutic area.

Connecting the Dots Across the Patient Journey

A patient’s journey to care often involves navigating fragmented systems, unclear processes, and delays. The research shows that patients are increasingly looking to pharmaceutical organizations to streamline processes and help bridge barriers to care, ensuring patients receive the timely, personalized health services they deserve while reducing the administrative burden on healthcare stakeholders.

For biopharma companies, a well-executed DTP strategy means the ability to deliver a more effective and holistic patient experience. By offering a platform that unifies critical components of care delivery, pharma orgs will enhance patient engagement, and reduce barriers to care while keeping providers at the center of every decision.

Meeting consumer expectations for digital engagement improves their perception of biopharma

Patients are actively seeking more robust and personalized digital tools and virtual care options to help them get connected with the right care in a timely and affordable manner, and more than half of these consumers³ expect to be able to find the information they’re looking for in three clicks or less.

ixlayer’s survey of healthcare consumers across several condition areas found they are motivated to use digital healthcare tools like the ones found in DTP programs – and much more likely to think positively of the pharma companies that provide them.⁴ In fact, 65% simply expect pharma companies to be doing so already.⁵

Deploying an integrated, patient-centric experience

Crafting a thoughtful, high-value DTP program is no easy task, especially when pharma companies need to address so many complex challenges. As precision medicine and changing consumer demands add even more pressure to get it right, company leaders need to consider the best way to deploy industry-leading experiences that tick all the boxes for consumers across disparate health needs

A unified solution with a pre-built infrastructure that is completely configurable to meet unique brand needs may be the answer. It also drastically reduces the investment and internal resources required to get started on deploying a holistic consumer journey, from patient onboarding and diagnostics to telehealth services and prescription fulfillment.

With a platform solution, integration is assured from the start, and companies can easily launch a seamless, consistent experience for both patients and internal teams.

ixlayer’s platform, ixEngage, can assist pharma companies with launching and administering fully compliant DTP programs by providing the infrastructure needed for rapid deployment and a seamless, intuitive patient experience. As the healthcare industry continues to evolve, platforms like ixEngage are setting the standard for direct-to-patient engagement, delivering on the promise of personalized, timely, and accessible care for all.

Footnotes:

¹ https://www.zs.com/insights/trends-shaping-pharmaceutical-landscape-2024-and-beyond

² ixInsights 2025 / Ipsos Patient research, Top 2 Box, Base All n=414 individuals with one of the following conditions: respiratory conditions, asthma, COPD, type 2 diabetes, heart disease, dermatologic conditions, psoriasis, or atopic dermatitis. – On a scale from 1 to 5, where 1 is strongly disagree and 5 is strongly agree, please rate how much you agree or disagree with the following statements: “Pharmaceutical companies should provide resources to patients to help them get the care and medicines they need.”

³ https://www.salesforce.com/content/dam/web/en_us/www/documents/reports/ connected-healthcare-consumer-report.pdf

⁴ ixInsights 2025 / Ipsos Patient research: If a digital health solution offered the following features, how likely would you be to use it?; If a biopharma company were to offer a digital solution with the following attributes how, if at all, would it change your perception of the company? Top 2 Box Base All: n=414 individuals with one of the following conditions: respiratory conditions, asthma, COPD, type 2 diabetes, heart disease, dermatologic conditions, psoriasis, or atopic dermatitis.

⁵ ixInsights 2025 / Ipsos Patient research, Top 2 Box, Base All n=414 individuals with one of the following conditions: respiratory conditions, asthma, COPD, type 2 diabetes, heart disease, dermatologic conditions, psoriasis, or atopic dermatitis. – On a scale from 1 to 5, where 1 is strongly disagree and 5 is strongly agree, please rate how much you agree or disagree with the following statements: “I expect a pharmaceutical company to provide additional resources to help me get the care and medication I need.”

Health and wellness marketers have no shortage of challenges. Staying relevant with health-conscious consumers. Navigating strict compliance regulations. Finding ways to stand out and connect with the right consumer in a stacked marketplace – to name a few.

The rewards are there, though, for brands who can break through. The $1.8 trillion global health and wellness market¹ only continues to grow. And many of those consumers are turning to the powerful influence of weather to make their health and wellness decisions. That’s one reason why we recently modernized and enhanced The Weather Channel app user experience as well as our AI-powered ad tech and back-end data modeling with an extra emphasis on health and well-being. Which brings health and wellness marketers a unique and relevant set of advertising solutions to fuel brand relevance and growth.

Unpacking the weather-wellness connection

The connection is clear: Habitually checking the weather informs more than how to dress for the elements. Recent research shows that weather inspires action to minimize illness, manage symptoms, and maximize time outside; offers a sense of control on quality of life; and guides purchases to maintain a healthy lifestyle. According to consumers in the study:

• 88% are focusing more on health and wellness in recent years²
• 76% use weather information to manage their health, up 33% since 2020²
• 73% are more concerned this year than previous years about at least one health condition²

The go-to health and wellness marketing partner 

Your customers realize weather’s impact, so meet them where they are. Trusted, accurate data, innovative AI in weather prediction, and brand-safe, contextually relevant content from The Weather Company, place your brand in the direct path of qualified audiences and their health decisions. Additionally, by understanding the effect of weather on consumer spending, we can better tailor our advertising strategies to influence purchasing decisions that are directly related to health and wellness.

Better accuracy, better engagement, better performance

A constant companion, weather influences daily habits and decisions, sunrise to sunset. But not all weather forecasts are equal. Or accurate. Not only are we the most accurate forecaster³ and one of America's most trusted brands,⁴ The Weather Channel is the preferred weather source used by health-conscious consumers to manage health across all conditions.

76% choose The Weather Channel over a competitor².

Since launching new wellness features in The Weather Channel app, we’ve seen 3x higher clicks into our wellness forecast experiences.⁵ In fact, compared to the legacy app experience, we’re already seeing:

• 11% more stickiness⁵
• 10% more page views per visit⁵
• 8% increase in time spent per daily active user⁵

This preference for, and engagement with, our digital channels means more reach and a higher likelihood of campaign success. But beyond the lure of our new features, the instability and volatility of Mother Nature herself means more eyeballs, more often, on the forecast.

IQVIA-validated health audiences 

IQVIA, a leader in healthcare intelligence, utilizes rich prescription data to provide insights into the types of visitors on digital platforms. Our new IQVIA partnership has validated that The Weather Channel's platforms effectively reach qualified health audiences across over 60 health conditions. Notably, we connect with 47% of U.S. psoriasis patients, which over indexes the general population by 32%.⁶ This collaboration validates our ability to deliver health content to audiences most likely to be treating health conditions and wanting to learn about weather’s impact on their symptoms.

Brand-safe sponsorships

Get your brand seen in the well-placed context of weather information and health resources through sponsorships on our digital properties.

Content sponsorships: With the latest enhancements to The Weather Channel app, we’ve re-imagined the experience to emphasize the weather-to-wellness connection. New editorial sponsorship opportunities help you align your brand with premium, health-related articles and video content created by award-winning journalists and verified by medical reviewers. Trusted advice and resources cover psoriasis, eczema, weight loss, type 2 diabetes, asthma, COPD, arthritis, stress management, aches and pains, and migraines.

Forecast sponsorships: Health-conscious consumers have access to a range of customized forecasts and tools designed for allergies, skin care, colds and flu, and respiratory health. These forecasts use weather data, AI, and insights to help predict how symptoms might change in the coming days and week.

69% check weather proactively for preventative health measures²

We put weather into action to give your audience information and insights that help them ultimately live healthier, happier, safer, and smarter.

Anticipate consumer needs with actionable data signals

By using weather data to inform when and where consumers’ health will be impacted, health marketers can tap into unified, scaled, and predictive signals to help to find and connect with qualified audiences and influence health outcomes.

Weather Targeting

Deliver hyperlocal, targeted, personalized health ads by leveraging an intelligent mix of weather data and health data, including:

• OTC/prescription sales from IQVIA
• Anonymized patient reports and aggregated insurance claims reports from Merative
• Weather science to identify the optimal mix of environmental elements most likely to exacerbate health conditions at a ZIP code level

Audience Targeting

In healthcare marketing, privacy is paramount. Find and connect with your audience using demographic look-alikes with a propensity for specific conditions. These representative audience models are based on:

• Behaviors and insights from The Weather Channel digital properties, including site interests and frequent locations viewed
• Anonymized health claims data
• CDC and other third-party sources

360M+ monthly global The Weather Channel app users⁶

Beyond the marketing department 

Make weather your business. The Weather Company can help you improve strategies, operations, and profitability across the enterprise. Yes, the same company that uses meteorological expertise and technology to help keep billions of people safe and informed about the weather also helps thousands of businesses increase the bottom line.

Weather Engine™

Help your business adapt quickly and make informed decisions that account for weather impacts. Powered by proprietary AI and machine learning, our Weather Engine helps you take advantage of large, analytics-driven insights across internal processes and consumer-facing touchpoints.

Weather data APIs

Integrate reliable weather data directly into your enterprise applications, business processes, or own custom models. Both weather data and insights are available via APIs with flexible integration services.

Competitive advantage is in the forecast

The influence of weather on daily health and wellness choices isn’t slowing down. Marketers need ways to stand out in a crowded, challenging market. Fortunately, as weather, data, and health continue to intersect, you can trust The Weather Company’s advertising solutions to help you create purposeful, relevant connections and better outcomes for both consumers and your business.

View footnote details+

1 The trends defining the $1.8 trillion global wellness market in 2024, McKinsey, January 16, 2024 Article

2 Weather and Health Impact Study, Sago for The Weather Company, health-affected consumers, March 2024

3 ForecastWatch, Global and Regional Weather Forecast Accuracy Overview, 2017-2022, commissioned by The Weather Company

4 According to a Morning Consult Q1 2024 survey: The Weather Channel brand was the #13 most trusted brand in the US. The surveys were conducted from 1/1/2024 through 3/31/2024, among a nationally representative sample of 1,158 and 35,280 U.S. adults

5 Amplitude, April-July 2024

6 IQVIA Healthratings – MAT June 2024; Data is anonymized and based on 1 month IQVIA sample of TWC audience. TWC has no actual health knowledge of any individual audience member7 According to Comscore, The Weather Channel was the largest provider of weather forecasts worldwide (web and app) in 2022 based on the average of the total monthly unique visitors. Comscore Media Metrix®, Worldwide Rollup Media Trend, News/Information – Weather category incl. The [M] Weather Channel, The, Jan-Dec. 2022 avg